Ketamine, a drug primarily used for starting and maintaining anesthesia, has gained traction as a potential treatment for conditions like depression, chronic pain, and certain psychiatric disorders. One mode of its administration is oral dissolvable tablets (ODT). For safe and effective usage of Ketamine ODTs, one must adhere to best practices.

1. Understand the Purpose:

Ketamine oral tablets may not be for everyone. They are typically used for patients unresponsive to conventional treatments. Recognize the purpose and potential benefits to set realistic expectations.

2. Follow Prescribed Dosages:

Self-medication or alteration of the prescribed dosage can be harmful. Dosages vary based on medical conditions, body weight, and individual response to the treatment.

3. Administering the ODT:

  • Clean Hands First: Always ensure your hands are clean before handling the tablet.
  • Handling: Using dry hands, remove the tablet from its packaging.
  • Placement: Place the tablet under the tongue.
  • Dissolving: Allow the tablet to dissolve completely for 20 to 30 minutes. Avoid chewing or swallowing it.
  • Post Dissolution: It’s advisable to spit rather than swallow the dissolved content.
  • Eating and Drinking: Refrain from eating for at least an hour before taking the tablet. After it’s dissolved, avoid eating or drinking for another hour to ensure optimal absorption.

4. Avoid Alcohol and Other Drugs:

The combined effects of Ketamine with alcohol or other drugs can be unpredictable and dangerous. Consult your healthcare provider regarding other medications.

5. Monitor Side Effects:

Report side effects like nausea, blood pressure fluctuations, hallucinations, or dizziness. Seek immediate medical attention for severe reactions.

6. Stay Off Heavy Machinery:

Ketamine can impair judgment and coordination. Refrain from driving or operating machinery after taking your dose until you know how it affects you.

7. Regular Check-ins:

Scheduled appointments with your healthcare provider can help in monitoring the drug’s impact and side effects, adjusting dosages if needed.

8. Proper Storage:

Keep tablets at room temperature, shielded from moisture and heat. Ensure they remain inaccessible to children or pets.

9. Maintain a Treatment Diary:

Recording your medication timings, side effects, and its effectiveness can offer valuable insights to you and your healthcare provider.

10. Informed Consent:

Stay informed about the potential risks and benefits of Ketamine. Engage in open dialogue with your healthcare provider about concerns.

11. Comprehensive Treatment:

Ketamine is one piece of the treatment puzzle. It should be complemented with therapy, lifestyle changes, and other treatments.

12. Exercise Patience:

Immediate relief is not guaranteed. Maintain consistent communication with your healthcare provider and monitor the treatment’s progress.


Ketamine ODTs present a promising approach to treating certain conditions. However, they demand adherence to best practices for optimal results. Establishing open lines of communication with healthcare professionals and staying informed are pivotal to the success of the treatment.

Disclaimer: This article provides general information and does not replace medical advice. Always consult a healthcare provider for personalized guidance.